Research carried out by Oxford University's Wellcome Trust Centre and Cancer Research UK has linked two faulty genes with the development of bowel cancer within families.
Oxford University researchers have located two genetic faults which
increase the risk of individuals with a history of bowel cancer in the
family developing it themselves.
The research was carried out by the Wellcome Trust Centre for Human
Genetics in Oxford and Cancer Research UK, and established a high
correlation between bowel cancer development and mutations in two
specific genes, POLE and POLD1, which are involved in the DNA repairing
The research found that defects in these genes can cause an
accumulation of DNA damage in the body that may contribute to bowel
The Cancer Research UK-funded project selected twenty people as study
subjects, eight of which had previously been diagnosed with bowel
cancer whilst the rest had a first-degree relative who developed the
illness. After sequencing the genomes of the 20 participants, the
scientists found both of the faulty genes in all subjects with bowel cancer or malignant tumours in the bowel.
To further consolidate the result, the research team broadened their
inspection base to 4000 people with bowel cancer and a control group of
6700 without the disease. Not a single case of genetic deficiencies in
POLE or POLD1 was found in the control group, while the researchers
found 12 people with POLE fault and one person with POLD1 fault in the
bowel cancer group.
Read more - http://www.cherwell.org/news/uk/2013/01/06/oxford-researchers-locate-highrisk-genes-for-bowel-cancer