Tuesday, 24 April 2012

Researchers close in on new way to treat aggressive bowel cancers

Targeting a "previously unappreciated" protein could lead to a treatment for aggressive bowel cancers, US researchers have found.
The finding, published in the journal Cell, could apply to up to a quarter of people who develop the disease.
But UK experts warned that, while the research was exciting, drugs targeting TAK1 - previously linked to inflammation - could be some years away.
Two genes - APC and KRAS - drive most bowel cancers. Around eight out of ten bowel cancers carries a faulty APC gene, whereas about half have a faulty KRAS gene.
Cancers in which both of these genes are defective are generally hardest to treat, and new-generation targeted treatments like cetuximab tend not to work in these patients.

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